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We generated homodimeric (EGFRxEGFR or HER2xHER2) and heterodimeric (EGFRxHER2) T cell-engaging bispecific antibodies (T-BsAbs) to direct polyclonal T cells to these antigens on pancreatic tumors. Here's an introduction to the five human design types (manifestors, generators, manifesting generators, projectors, and reflectors) and what makes each one tick. By understanding and embracing your unique design, you can navigate your journey with wisdom and grace, becoming a role model for others and leaving a lasting impact on the world.
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By embracing the inherent qualities of leadership, wisdom, and introspection, individuals with this profile are empowered to navigate life's challenges with grace and authenticity. Through a process of introspection and self-discovery, they uncover their true potential and emerge as beacons of inspiration and guidance for others. As the 2 is also contained in the 6/2 profile, it carries within the search for a calling. The dilemma for the 6/2 profile is that it follows the wrong calling in the first 30 years of trial and error and stays stuck in there for quite a while.
2 Manifesting Generator Profile in Human Design
This can be a period of introspection and self-discovery, where you digest the experiences and lessons from the first phase. It’s a time to discover who you are beyond societal expectations and conditioning. The Manifesting Generator energy brings a powerful drive and a capacity for multitasking. You are designed to respond to life, initiating action once your gut gives you the green light. You have a lot of energy and can accomplish many things in a short amount of time, especially when you’re passionate about what you’re doing. For partners of 6/2 individuals, it’s essential to recognize this dynamic.
Embracing the Journey: The Life of a 6/2 Manifestor
Find ways to connect with others that feel good to you, whether that’s through teaching, mentoring, sharing your creations, or simply by being yourself. One of the key aspects of the 6/2 Manifesting Generator profile is the three-part life process. This process involves a period of experimentation, a phase of retreat and introspection, and finally, stepping into the role of a wise and experienced Role Model. However, despite your need for alone time, there’s a paradox within your design. You’re here to be a Role Model and to share your wisdom and experiences with others.
This is a genetically noble Profile, but only if he lives his True Self correctly. In a False Manifestation, a person with a 6/2 Profile can become a Role Model, for example, in hypocrisy and give advice and moral assessments that he himself is not going to live by. But this is at the level of the 6th Personality Line, and at the level of the Body, that is, unconsciously, such a person strives for solitude. In a company or at a party, he will choose a place in which it is convenient to observe what is happening, while remaining on the sidelines. For example, he can sit on a windowsill, a separate table, or, at the very least, choose a place at a common table, from which it will be easiest to retreat at a moment of excessive attention. 6/2 profiles are in the company of Elton John, Bruce Lee, Marilyn Monroe, Pamela Anderson, Charles Dickens, Emily Bronte, Barack Obama and Matthew McConaughy.
"Human design composites those two and layers them on top of each other and then looks at how [their] energy interacts," she explains. But as human design experts Dana Stiles and Shayna Cornelius of DayLuna tell mbg, human design actually combines a number of different ancient systems. Whatever your authority is, learning to trust and rely on it is a significant part of your journey as a 6/2 Manifestor. It enables you to make decisions and take actions that are true to your nature and serve your purpose in life. This strategy may sometimes feel uncomfortable or unnecessary, but it is a vital aspect of living as a 6/2 Manifestor.
As they transition into the third phase of their life, around the age of fifty, they often emerge as role models, leaders in their chosen fields. The accumulated wisdom and experience now position them to guide, mentor, and lead. Their career choices during this phase often reflect this guiding light role. Following this experimental phase, there’s a shift to a more observational stance, almost as if they are on the “rooftop”, reflecting upon their experiences and gathering wisdom. Careers during this phase may lean towards research, analysis, or roles that require a deeper understanding of patterns. During the first phase, up to around age 30, you’re in a phase of trial and error.
Flow analysis of tumors revealed a higher proportion of human CD45+ cells in HER2 and EGFRxHER2 T-BsAb-treated tumors, representing greater presence of TILs. HER2xHER2 T-BsAbs elicited greater T cell infiltration than EGFRxHER2 T-BsAbs (Fig. 4B), while EGFRxEGFR T-BsAb treatment showed no significant increase in TILs compared to untreated tumors. T-BsAb treatment also increased the activation and cytokine production of TILs (Fig. 4C). All T-BsAb treatments increased the proportion of IFN-γ+TNF-α+ among human CD45+ T cells. All three T-BsAb treatments also elevated the expression of activation marker CD69 among both CD4+ and CD8+ TILs, although EGFR T-BsAb treatment did not significantly increase CD69 among CD4+ TILs. In the present study, we characterize the biochemical and cytotoxic properties of EGFRxEGFR, HER2xHER2 and EGFRxHER2 T-BsAbs built on the IgG-[L]-scFv format.
This phase allows you to develop resilience and understand the world around you. The life of a 6/2 Projector is typically marked by three distinct phases. Understanding these phases can provide valuable insights into your life journey. In your second phase, you have the opportunity to reflect on the lessons you’ve learned and integrate them into your life. Embrace this period of introspection and withdrawal, as it’s an essential part of your growth process.
And in the decades since, human design has steadily gained popularity around the world. However, it’s important for 6/2 Manifestors to remember to take care of their energy. Their impactful presence can sometimes be demanding, and they need to ensure they take time to rest and recharge. This way, they can maintain their influence without sacrificing their well-being. For a 6/2 Manifestor, informing is a key strategy to reduce resistance from others and to foster understanding and cooperation.
This means that while you need your alone time to recharge and delve into your interests, you also need to engage with the world to fulfill your purpose. However, more explorative profiles like 3/5 can also resonate well, given the shared love for discovery and understanding. Their combined energies can lead to a dynamic, ever-evolving relationship. For partners of 6/2 individuals, it’s crucial not to take this need for solitude personally. It’s not a reflection of their adequacy or the quality of the relationship. Meanwhile, the 2nd line, the hermit, craves solitude and introspection.
Beyond formal educational structures, they can also thrive as life coaches, personal development trainers, or even spiritual guides. The key is a platform that allows them to impart wisdom, guide, and inspire. The 6/2 profile is an intriguing blend of outgoing and inward-focused energy. Remember, it’s not about choosing one over the other, but rather about finding a balance that allows you to honor both aspects of your profile. However, remember that it’s equally important to inform others before you initiate action.
They may experience a sense of restlessness or frustration during these transitions. However, these transitions also offer opportunities for growth and deeper self-understanding. Navigating these transitions requires understanding and acceptance of their unique profile dynamics. By embracing their need for solitude and recognizing the value of their experiences, 6/2 individuals can navigate these transitions with grace and wisdom. In the first phase, they are explorers, learning about the world through trial and error. This phase is characterized by a sense of restlessness and a desire to understand the world in a deeper sense.
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Even parenting can be difficult during this time, especially if you don’t understand what is happening to you. During this first stage, your life is all about experiences and experimentation. On one hand, these individuals can be seen as capable and wise advisors; on the other hand, they need clearly defined boundaries to meet their needs for solitude. The challenge lies in finding partners who respect their needs for independence and value their problem-solving abilities. The second line, the Hermit, introduces a preference for solitude and personal space into the profile.
In your role as a Role Model, you have a natural capacity to inspire and guide others, simply by being yourself and living according to your design. You do not need to actively seek out this role; it comes naturally to you as you live out your true self. As a 6/2 Generator, you possess a consistent life force energy that needs to be used productively each day. Understanding and managing your energy correctly is crucial for maintaining balance and avoiding feelings of frustration – the signature sign that you’re not living according to your design. The third phase (post approximately 50) is when you step into your role as a Role Model. By now, you’ve gained enough wisdom and experience to guide others, sharing the insights you’ve gleaned from your journey.
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